STUDIES

Please reach out if you are interested in performing any research or clinical studies regarding TuttleNumbNow. We are happy to help in any way. 

Efficacy of the TuttleNumbNow anesthesia protocol for mandibular first molars: a retrospective study

JDAPM Volume 26, Issue 2 (April 1, 2026)

Gregory K. Tuttle, Carter K. Newell, LaDawn Boucher, Jill Taylor, and Jared J. Tuttle

https://jdapm.org/DOIx.php?id=10.17245/jdapm.2026.26.2.133 

Below is a list of related studies:

• Intraosseous (IO) injections allows placement of local anesthetic solution directly into the cancellous bone adjacent to the tooth to be anesthetized
  
  • Reader, Alfred, John Nusstein, and Melissa Drum. Successful local anesthesia for restorative dentistry and endodontics. Quintessence Publishing Company Incorporated, 2017.p.132
    
  • https://pubmed.ncbi.nlm.nih.gov/38266911/
• Scalpel Designed Bevel Studies- a significant lower pain level was found in Scalpel Bevel
  • M. Dau, I. Buttchereit, C. Ganz, B. Frerich, E.N. Anisimova, M. Daubländer, P.W. Kämmerer, Influence of needle bevel design on injection pain and needle deformation in dental local infiltration anaesthesia – randomized clinical trial, International Journal of Oral and Maxillofacial Surgery,Volume 46, Issue 11,2017,Pages 1484-1489ISSN 0901-5027
    
  • https://www.sciencedirect.com/science/article/abs/pii/S0901502717315217
• 50 years since new local anesthesia technique was invented by Gow Gates with an alternative to the IA Nerve Block
  
  • Isen, David. "FEATURES-PRODUCT PROFILE-A New Method for Intraosseus Injection: The X-Tip." Oral Health 90.7 (2000): 44-46.
    
  • https://www.oralhealthgroup.com/features/product-profile-a-new-method-for-intraosseus-injection-the-x-tip/
    
• Needle Gauge Length
  • Webb, Laura J. "Orabloc®."
    
  • https://www.orabloc.com/wp-content/uploads/Tip-Selecting-the-right-needle.pdf
• Needle Bending Study-
  • Tuttle JJ, Davidson AD, Tuttle GK. Bending 30-gauge needles using a needle guide: fatigue life evaluation. J Dent Anesth Pain Med. 2023 Oct;23(5):281-285. 
    
  • https://jdapm.org/DOIx.php?id=10.17245/jdapm.2023.23.5.281
• For a “hot tooth” with symptomatic irreversible pulpitis (SIP), an IAN is only 64% effective
  • Reader A, Nusstein J, Drum M. Successful Local Anesthesia for Restorative Dentistry and Endodontics, Quintessence Publishing Co, Inc. Hanover Park, IL. 2011, p 34, 133, 134, 135, 138, 139, 140, 159.
  • https://www.aae.org/specialty/successful-local-anesthesia-what-endodontists-need-to-know/
  • Reader, Successful Local Anesthesia: What Endodontists Need to Know, 2017
    
• The IAN not only falls short statistically in dental local anesthesia, but also among all local anesthetic blocks in medicine
  
  • Thangavelu, K., R. Kannan, and N. Senthil Kumar. "Inferior alveolar nerve block: Alternative technique." Anesthesia, essays and researches 6.1 (2012): 53.
    
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173425/
  • Advantageous to find an alternative simple technique
    
• TuttleNumbNow Intraosseous injection comparison with buccal infiltration for pulpal anesthesia in mandibular first molars.
  • Efficacy of the TuttleNumbNow Intraosseous Method for Pulpal Anesthesia in the Mandibular First Molar: A Prospective, Randomized, Crossover Study
  • https://pubmed.ncbi.nlm.nih.gov/38266911/
• Increased Anesthetic Requirement in Individuals with Red Hair: Phenotypic and Genotypic Correlation
  • Red hair appears to be a distinct phenotype linked to anesthetic requirement in humans that can also be traced to a specific genotype.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1362956/